W
W. with the condensation of palmitoyl coenzyme A (CoA) and serine by serine palmitoyltransferase (SPT), an enzyme that is negatively controlled by ORM1-like protein 3 (ORMDL3). This is followed by a series of reactions (catalysed by enzymes in reddish) leading to formation of ceramide and subsequent formation of sphingomyelin and glycosphingolipids. Ceramide can be metabolized…