Finding, in vivo activity, and system of action of the little\molecule p53 activator
Finding, in vivo activity, and system of action of the little\molecule p53 activator. cells of LKB1 position regardless. The marked decrease in SIRT1 manifestation by mix of metformin and tenovin\6 improved acetylation of p53 at lysine 382 and improved p53 balance in LKB1\lacking A549 cells. The mixture suppressed SIRT1 promoter activity better than either agent…