The increased chromatin levels and phosphorylation of RPA upon loss of histone H1 also suggested the premature collapse of replication forks
The increased chromatin levels and phosphorylation of RPA upon loss of histone H1 also suggested the premature collapse of replication forks. crucial for life in eukaryotes. Importantly, DNA damage caused by endogenous and external sources threatens the activity and processivity of the replication machinery and requires dedicated pathways for DNA repair (Cortez, 2019). For instance,…