We found that artificial activation and ligand occupancy of the integrin is enough to dissociate JAM-A from the integrin (Figure 1I)
We found that artificial activation and ligand occupancy of the integrin is enough to dissociate JAM-A from the integrin (Figure 1I). Open in a separate window Figure 1 JAM-A interacts with the integrin IIb3. integrin-associated c-Src in an inactive state by phosphorylating Y529 in its regulatory domain. Absence of JAM-A results in impaired c-SrcY529 phosphorylation…