The B/C Helix, shown in red, undergoes dramatic conformational rearrangement

The B/C Helix, shown in red, undergoes dramatic conformational rearrangement. N-terminal dimerization/docking website to bind with high affinity to A Kinase Anchoring Proteins using an amphipathic helical motif. This targeting mechanism, which localizes PKA near to its protein substrates, is also a target Rabbit Polyclonal to NCAM2 for restorative treatment of PKA signaling. regulatory element…