Further research have revealed that E and ORF3a of SARS-CoV activate NLRP3 inflammasome by changing the K+ ion permeability of plasma membrane as well as the production of mitochondrial reactive air species23,24
Further research have revealed that E and ORF3a of SARS-CoV activate NLRP3 inflammasome by changing the K+ ion permeability of plasma membrane as well as the production of mitochondrial reactive air species23,24. proteins interacts with NLRP3 proteins straight, promotes the binding of NLRP3 with ASC, and facilitates NLRP3 inflammasome set up. Moreover, N proteins aggravates…