However, the entire amount of colonies seen in the absence of LIF was reduced by approximately 60% (Fig
However, the entire amount of colonies seen in the absence of LIF was reduced by approximately 60% (Fig.4B), suggesting that differentiation may be associated with increased cell death. Therefore, LSD1 regulates the manifestation and appropriate timing of important developmental regulators, as part of the LSD1/CoREST/HDAC complex, during early embryonic development. The methylation of lysine residues…