Volkwein, and T
Volkwein, and T. proteasome. Endoplasmic reticulum (ER)-connected degradation (ERAD) is definitely a quality control process that selectively eliminates aberrant proteins in the secretory pathway. Protein substrates of ERAD are dislocated from your ER to the cytosol, where they may be ubiquitinated and degraded from the proteasome (5). The Sec61p translocon is definitely involved both in…