Replication of these results in major neurons facilitates the relevance of faulty autophagy in SPG15-related neurodegeneration
Replication of these results in major neurons facilitates the relevance of faulty autophagy in SPG15-related neurodegeneration. Keywords: difficult hereditary spastic paraparesis, SPG15, autophagy, autophagosome maturation, ZFYVE26/SPASTIZIN, BECN1/Beclin you Autophagy is known as a conserved intracellular catabolic procedure that provides cytoplasmic constituents to lysosomes for destruction and recycling where possible through the development of double-membrane vacuoles,…