All authors reviewed the results and approved the final version of the manuscript

All authors reviewed the results and approved the final version of the manuscript. ACKNOWLEDGMENTS This study was supported from the Swedish State Support for Clinical Research (https://www.alfvastragotaland.se, ALFGBG\717531 [Magnus Gissln] and 679621 [Susannah Leach]), SciLifeLab/KAW national COVID\19 research system (https://www.scilifelab.se/covid-19#nationalprogram, V\2020\ 0250 [Magnus Gissln]) and Sweden’s Advancement Agency (Vinnova) project ID 2020\02205 (Ali M. the…

Further research have revealed that E and ORF3a of SARS-CoV activate NLRP3 inflammasome by changing the K+ ion permeability of plasma membrane as well as the production of mitochondrial reactive air species23,24

Further research have revealed that E and ORF3a of SARS-CoV activate NLRP3 inflammasome by changing the K+ ion permeability of plasma membrane as well as the production of mitochondrial reactive air species23,24. proteins interacts with NLRP3 proteins straight, promotes the binding of NLRP3 with ASC, and facilitates NLRP3 inflammasome set up. Moreover, N proteins aggravates…