The prevalence of potentially inappropriate medication in private health health or service plan was 15.9% (95%CI 14.7C17.1) and in the prescriptions of the SUS it was 17.1% (95%CI 15.5C18.7). Among the 898 medications utilized for the nervous system, 458 were considered as inappropriate. older adults. Special attention should be given to the older adults who use polypharmacy. Specific lists should be created with more appropriate medications for the older ML348 populace in the National Essential Medicine List. commands, specific for the analysis of complex sample-based surveys, of the statistical program Stata 12.1. We performed the description of the sample in relation to the impartial variables and calculated the prevalence of the outcome of potentially improper medications with the respective confidence intervals. We calculated the prevalence ratios, 95% confidence intervals, and Wald test for heterogeneity and linear pattern (in the case of ordinal variables) in the crude and adjusted analysis. The update of the Beers criteria published in 20121 was used to analyze potentially improper medications. We questioned the diagnoses that could classify medications as improper, according to these ML348 criteria: heart failure, syncope, epilepsy, dementia or cognitive loss, falls or fractures, insomnia, Parkinsons disease, chronic constipation, gastric or duodenal ulcer, chronic kidney disease, urinary incontinence, and prostatic hyperplasia. We chose Rabbit Polyclonal to ELOA3 to not question the occurrence of delirium, because of the complexity of the diagnosis. In some cases, we also needed to know the dose, dosage, or route of administration of the medication used. The adjusted analyses were conducted using Poisson regression in two hierarchical levels, keeping in the first level the demographic variables C race, age, and gender C and socioeconomic variables C education and socioeconomic level. In the second level, we included the variables of polypharmacy, self-medication, and burden of disease. We used the total number of older individuals as denominator for the analysis of the prevalence of potentially improper medications and associated factors. The total quantity of medications used was used as denominator to characterize the medications for pharmacological groups. The study was approved by the Research Ethics Committee of the (Opinion 472.357/2013). The interviews were conducted after signing the informed consent, with a guarantee of confidentiality. RESULTS The number of older individuals found was 1,844, with 21.3% (n = 393) of losses and refusals, amounting to 1 1,451 interviews with older individuals. Women accounted for 63.0% of the sample. Most participants were aged between 60 and 69 years, were white, and experienced up to three full years of study. More than half of the sample belonged to the socioeconomic level C. Approximately 60.0% of the older adults reported up to three morbidities. Among the respondents, 1,305 reported the use of medication in the 15 days prior to the interview. It was reported the use of 5,700 medications. The most commonly used pharmacological group according to the ATC classification was medications for the cardiovascular system (43.9%), followed by medications for the alimentary tract and metabolism (18.9%), nervous system (15.8%), blood and hematopoietic organs (6.3%), and musculoskeletal system (5.6%). Other pharmacological groups experienced frequency of use of less than 5.0%. Among the 5,700 medications, 5,651 were assessed to see if they were improper. Of these, 937 were ML348 considered as potentially improper according to the 2012 Beers criteria (16.6%). Among the older adults, 42.4% (95%CI 39.8C44.9) used at least one PIM. We assessed 5,661 medications regarding the origin of the prescription: 60.3% were prescribed by private physician or dentist or those of health plans and 37.6% were prescribed by physician or dentist of the SUS. Only 2.1% of the medications were used by self-medication. The prevalence of potentially improper medication in private health support or health plan was 15.9% (95%CI 14.7C17.1) and in the prescriptions of the SUS it was 17.1% (95%CI 15.5C18.7). Among the 898 medications utilized for the nervous system, 458 were considered as improper. This group accounted for 48.9% of the total PIM. The second group with the highest quantity of PIM was for the musculoskeletal system. Of that group, 316 medications were used, and 169 were considered as improper (18.0%). Medication for the cardiovascular system corresponded to.